CCR3 Expression and Function in Asthmatic Airway Smooth Muscle Cells
نویسندگان
چکیده
منابع مشابه
CCR3 expression and function in asthmatic airway smooth muscle cells.
Asthma is characterized by an increase in airway smooth muscle mass and a decreased distance between the smooth muscle layer and the epithelium. Furthermore, there is evidence to indicate that airway smooth muscle cells (ASMC) express a wide variety of receptors involved in the immune response. The aims of this study were to examine the expression of CCR3 on ASMC, to compare this expression bet...
متن کاملMechanical properties of asthmatic airway smooth muscle.
Airway smooth muscle (ASM) is the major effector of excessive airway narrowing in asthma. Changes in some of the mechanical properties of ASM could contribute to excessive narrowing and have not been systematically studied in human ASM from nonasthmatic and asthmatic subjects. Human ASM strips (eight asthmatic and six nonasthmatic) were studied at in situ length and force was normalised to maxi...
متن کاملDifferential induction of CD38 expression by TNF- in asthmatic airway smooth muscle cells
Jude JA, Solway J, Panettieri RA Jr, Walseth TF, Kannan MS. Differential induction of CD38 expression by TNFin asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 299: L879–L890, 2010. First published August 6, 2010; doi:10.1152/ajplung.00021.2010.—The ADP-ribosyl cyclase activity of CD38, a membrane protein expressed in human airway smooth muscle (ASM) cells, generates cyc...
متن کاملInhaled corticosteroids inhibit substance P receptor expression in asthmatic rat airway smooth muscle cells
BACKGROUND Neurokinins (NKs) participate in asthmatic airway inflammation, but the effects of NKs on airway smooth muscle cells (ASMCs) and those of corticosteroids on NKs are unknown. METHODS To investigate the effect of budesonide on substance P (NK-1) receptor (NK-1R) expression in the lung and ASMCs, 45 Wistar rats were randomly divided into three groups: control, asthmatic, and budesonid...
متن کاملExpression of connective tissue growth factor in asthmatic airway smooth muscle cells.
There is strong evidence to implicate transforming growth factor-beta in the remodeling that occurs in asthma, as levels are increased in bronchial lavage fluid and gene expression is increased in bronchial tissue. Transforming growth factor-beta is also known to increase the release of collagen from airway smooth muscle. Here we identify for the first time a possible mechanism for the effects ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2005
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.175.4.2702